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KMID : 0043319930160020164
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Archives of Pharmacal Research
1993 Volume.16 No. 2 p.164 ~ p.167
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Synthesis of Pyrazolo [4,3-c]Pyridazine and Isoxazolo [3,4-d]Pyridazine Derivatives
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Abbass Ikhlass-M.
Sharaf Mohye-A.F.
El-damaty Alia-A.
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Abstract
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Arylhydrazones of diethyl acetonedicarboxylate 3 was treated with fomaldehyde to 1-aryl-1, 4, 5, 6-tetrahyeheypyridazine derivatives 4a-f Cyclization of compound 4a-f by hydroxy-lamine afforded [3, 4-d] 1, 4, 5, 6-tetrahydropyridazine derivative 5a-f. Also, cyclization of compound 4c with semicarbazide gave pyrazolote [4, 3-c] pyridazine 6. On the other hand compound 3 reacted with ethylothofomate to give diethyl-1, 4-dihydro-1-arypyridazine-4-one-3, 5 dicaboxylate 7, which on treatment with hydrazine, semicarbazide and thiosemicarbazide gave pyridazine, amido and thioamido derivatives. The spectrl and antimicrobial data of these compounds 1-8 were studied.
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KEYWORD
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Synthseis, Pyrazolo[4, 5]pyridazine, Isoxazolo[3, 4, -d]pyridazine, Antimicrobial activity
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